HOME | Career | Contact us
For Patients > Artiflo

COMPOSITION: Each uncoated tablet contains Nicoumalone 1mg/2mg/3mg/4mg.


INDICATIONS: Treatment and preventionof thromboembolic diseases.


CONTRAINDICATIONS: Pregnancy,hypersensitivity to nicoumalone and related coumarin derivatives or to the excipients of Artiflo, and in patients unable to co-operate (e.g. unsupervised patients with dementia, alcoholics and patients with psychiatric disorders). All conditions where the risk of haemorrhage exceeds possible clinical benefit  and in cases of increased fibrinolytic activity following operations on the lung, prostate or uterus etc.


ADVERSE EVENTS:Haemorrhage is the most common side-effect. Possible sites of haemorrhage include the gastro-intestinal tract, brain, urogenital tract, uterus, liver,gall bladder and the eye.


PRECAUTIONS: Caution should be exercised in patients with mild to moderate hepatic and renal impairment,  severe heart failure, patients with known or suspected (e.g. abnormal bleeding after injury) protein C or protein S deficiency. In paediatric and elderly patients (=65 years), caution and more frequent monitoring of PT/INR is recommended.


DOSAGE: The usual starting dose is between 2 mg/day to 4 mg/day without administration of a loading dose. Treatment may also be initiated with a loading dose regimen,usually 6 mg on the first day followed by 4 mg on the second day. The maintenance dose generally lies between 1 to 8mg daily depending on the individual patient, the underlying disease, clinical indication and desired intensity of anticoagulation. (For detailed information please write to Zuventus Healthcare Limited, 5119, 5th floor, D-Wing, Oberoi Garden Estates,Chandivali, Andheri (E), Mumbai 400 072 or email to medico@zuventus.com)

© 2013. All Rights Reserved. Zuventus HealthCare Ltd.