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COMPOSITION: Eachuncoated tablet contains Nicoumalone 1mg/2mg/3mg/4mg.


INDICATIONS: Treatment and preventionof thromboembolic diseases.


CONTRAINDICATIONS: Pregnancy,hypersensitivity to nicoumalone and related coumarin derivatives or to theexcipients of Artiflo, and in patients unable to co-operate (e.g. unsupervisedpatients with dementia, alcoholics and patients with psychiatric disorders). Allconditions where the risk of haemorrhage exceeds possible clinical benefit  and in cases of increased fibrinolyticactivity following operations on the lung, prostate or uterus etc.


ADVERSE EVENTS:Haemorrhage is the most common side-effect. Possible sites of haemorrhageinclude the gastro-intestinal tract, brain, urogenital tract, uterus, liver,gall bladder and the eye.


PRECAUTIONS: Cautionshould be exercised in patients with mild to moderate hepatic and renalimpairment,  severe heart failure, patientswith known or suspected (e.g. abnormal bleeding after injury) protein C orprotein S deficiency. In paediatric and elderly patients (=65 years), cautionand more frequent monitoring of PT/INR is recommended.


DOSAGE: Theusual starting dose is between 2 mg/day to 4 mg/day without administration of aloading dose. Treatment may also be initiated with a loading dose regimen,usually 6 mg on the first day followed by 4 mg on the second day. Themaintenance dose generally lies between 1 to 8mg daily depending on theindividual patient, the underlying disease, clinical indication and desiredintensity of anticoagulation. (For detailed information please write to ZuventusHealthcare Limited, 5119, 5th floor, D-Wing, Oberoi Garden Estates,Chandivali, Andheri (E), Mumbai 400 072 or email to medico@zuventus.com)

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